Terason is introducing a new tablet-based ultrasound system, the uSmart 3200T. The system has received both CE mark and FDA clearance and is the first in a series of uSmart products. The 3200T, aimed at point-of-care application in environments such as emergency medicine, anesthesia and critical care, is very compact and weighs less than 5 lbs. A dock is provided for recharging.
The uSmart 3200T runs on Windows 7 Touch and has a 128GB Solid State hard drive, WiFi, Bluetooth, USB 3.0, HDMI and an SD card slot. It features smart gestures, an adaptive touch screen, uConnect remote capabilities and a fast boot-up time. Imaging features include power doppler, enhanced needle imaging, omnibeam, 2D beam steering and trapezoidal imaging. A mobile cart is optionally available.
Most diseases involve the increased or decreased production of specific proteins, but these molecules are so hard to detect that using them as biomarkers for clinical diagnosis of disease has been very limited. Being able to spot target proteins can significantly expand the capabilities of hospital labs and lead to early detection and treatment of cancer and all kinds of other diseases
Now researchers at Brooklyn’s Polytechnic Institute of New York University (NYU-Poly) have created the first label-free system capable of detecting single protein molecules, including biomarkers for cancer and other diseases that are much smaller than any viruses. So far they demonstrated the technique on two proteins, including thyroglobulin, a human cancer biomarker, and believe the technology will be able to detect considerably smaller proteins.
In 2012, Arnold and his team were able to detect in solution the smallest known RNA virus, MS2, with a mass of 6 attograms. Now, with experimental work by postdoctoral fellow Venkata Dantham and former student David Keng, two proteins have been detected: a human cancer marker protein called Thyroglobulin, with a mass of just 1 attogram, and the bovine form of a common plasma protein, serum albumin, with a far smaller mass of 0.11 attogram. “An attogram is a millionth of a millionth of a millionth of a gram,” said Arnold, “and we believe that our new limit of detection may be smaller than 0.01 attogram.”
This latest milestone builds on a technique pioneered by Arnold and collaborators from NYU-Poly and Fordham University. In 2012, the researchers set the first sizing record by treating a novel biosensor with plasmonic gold nano-receptors, enhancing the electric field of the sensor and allowing even the smallest shifts in resonant frequency to be detected.
Letter in Nano Letters: Label-Free Detection of Single Protein Using a Nanoplasmonic-Photonic Hybrid Microcavity
People wearing prosthetic devices often suffer from the fact that limbs to which these devices attach can swell and and shrink throughout the day due to activity and dietary intake. Fitting the sockets to accommodate for this natural phenomenon could significantly improve the comfort and usability of prostheses. To this end researchers at University of Washington have developed a device that can measure and monitor the fluid volume of limbs inside prosthetic sockets while they’re being worn.
The device consists of electrodes attached to the skin and a processing unit the size of a cigarette pack that records the readings throughout the day. The monitoring system is already being tested in Seattle and San Francisco, and is to be used to test vacuum powered prosthetic sockets that inflate and deflate depending on the current needs of the user.
Researchers are testing the device by asking patients to go through a routine that includes sitting, standing and walking as the device records fluid changes. In the UW lab, Bailey does a series of 90-second exercises while wearing the portable device. Data is transmitted wirelessly to a tablet that displays the changes in his limb size about 15 times a second.
In the near term, researchers hope clinics could go through a similar routine to help track an individual’s swelling and shrinking patterns.
Longer term, researchers want to build a smaller device that patients could wear for a couple of weeks or longer to monitor changes in their limb size as they go about their daily routines.
The hope is that prosthetic limb sockets will become more robust and flexible, accommodating natural changes in swelling without causing discomfort or inconvenience.
This summer the team will work with patients across the U.S. and Canada who use vacuum-suction technology to help keep their residual limbs snug in the sockets and adjust the fit when tissues swell and shrink. Patients say this vacuum can help improve socket comfort and reduce pain, but the technology requires careful maintenance and it can be disruptive when the noisy vacuum turns on.
University of Washington: Pain of artificial legs could be eased by real-time monitoring
It took Nobel Prize-winning scientific work to make the bacteria Helicobacter pylori famous. Able to survive in the highly acidic environment of the stomach, it has been found to be the common cause of many peptic ulcers, so detecting its presence can help prevent and treat a disease that affects approximately 4.5 million people in the United States annually.
We’ve been following the BreathID device from Exalenz Bioscience for a few years now (flashbacks below) as it’s been going through clinical trials, and now the company is reporting that its BreathID Hp test for H. pylori is now being made available globally. The test takes about fifteen minutes and first involves sampling of unadulterated breath followed by the patient drinking a beverage containing non-radioactive, stable Carbon-13. The test is completed by taking multiple samples of exhaled breath and detecting 13CO2. Depending on the presence of H. pylori, the concentrations vary and results are displayed on the device’s readout screen.